Overviewof Pradofloxacin for Felines and Canines
- Pradofloxacin, marketed by the brand name Veraflox® by Bayer, is a broad-spectrum antibiotic used to treat infections in cats caused by susceptible bacteria. Pradofloxacin is primarily marketed for cats but can be used in dogs.
- Pradofloxacin is classified as a fluoroquinolone antibiotic with bactericidal properities against Gram-negative, Gram-positive and anaerobic bacteria.
- It is an oral suspension specifically marketing for cats for once daily dosing.
- Peak concentration can occur as early as one hour after dosing.
- Pradofloxacin is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.
Brand Names and Other Namesof Pradofloxacin
- Human formulations: None
- Veterinary formulations: Veraflox® (Bayer)
Uses of Pradofloxacinfor Cats and Dogs
- Pradofloxacin is used to treat a variety of infections, including skin infections, urinary tract infections, respiratory infections, and wound infections caused by susceptible bacteria.
- While Pradofloxacin is highly effective, some bacteria are resistant to its effects.
- Pradofloxacin is not effective for treating infections caused by viruses, parasites, or molds.
Precautions and Side Effects of Pradofloxacin
- Pradofloxacin is licensed for use in cats only in the United States. Not licensed for use in dogs in the US but is licensed for use in other countries.
- While generally safe and effective when prescribed by a veterinarian, Pradofloxacin can cause side effects in some animals. Pradofloxacin should not be used in dogs or cats with known hypersensitivity or allergy to the drug.
- Pradofloxacin is contraindicated in cats and dogs with a known hypersensitivity to quinolones.
- Pradofloxacin belongs to a class of antibiotics called fluoroquinolones which has been associated with the development of retinopathy and/or blindness.
- Pradofloxacin has not been approved for use in dogs in the U.S. Side effects include bone marrow suppression which can thrombocytopenia and neutropenia.
- Pradofloxacin is approved for use for a maximum of 7 days in cats. Administration can cause reversible drops in white blood cell counts. Drug should be discontinued if there is any unexplained drop in leukocyte, neutrophil and/or lymphocyte counts.
- Pradofloxacin should be used with caution in cats with central nervous system disease. Rare side effects may include seizures.
- Pradofloxacin is not approved for use in kittens under 6 weeks of age. Safety in pregnant or nursing cats has not been established. Pradofloxacin is generally not recommended for dogs less than 12 months of age.
- Young animals treated with Pradofloxacin may develop damage to the cartilage of their joints. Swollen joints and lameness are clinical signs that may be observed.
- Pradofloxacin has a good safety record and adverse reactions are uncommon. Occasionally, some animals develop diarrhea or loose stools from Pradofloxacin.
- Pradofloxacin may interact with other medications. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with Pradofloxacin. Such drugs include theophylline, antacids, iron supplements, sucralfate, cyclosporine and various other antibiotics.
How Pradofloxacin Is Supplied
- Pradofloxacin is available in liquid suspension in a concentration of 25 mg/ml. Two bottle sizes are available which includes
Dosing Information of Pradofloxacinfor Cats
- Medication should never be administered without first consulting your veterinarian.
- Please note: Pradofloxacin is approved for use in dogs in the UK and Europe but not approved for use in dogs in the United States. However, it is still commonly used in dogs. The packaging is marketed for cats and the packaging of Pradofloxacin reads "DO NOT USE IN DOGS".
- The typical dose administered to cats is 3.4 mg per pound per day (7.5 mg/kg per day) orally once daily for 7 consecutive days. Ideally should be given on an empty stomach if possible as this increases drug absorption.
- The typical dose administered to dogs is 1.5 to 2.2 mg per pound (3 to 4.5 mg/kg) once daily.
- The duration of treatment will depend on the condition being treated. For example, superficial skin infections (Pyoderma) may be treated for 14 to 21 days and deep skin infections for up 4 to 5 weeks, urinary tract infections for 7 to 21 days and other mild infections for as little as 7 days.
- Shake well before using. Store below 30°C (86°F).
- After initial opening, Veraflox™ has considered stable for 60 days.
- The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your dog or cat feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance.