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Fipronil and Cyphenothrin (Parastar Plus®, Fiproguard Max®) for Dogs

Fipronil and Cyphenothrin (Parastar Plus®, Fiproguard Max®) for Dogs

Overview of Using Parastar Plus or Fiproguard Max® in dogs Dogs

  • Parastar Plus® is the brand name for the generic agent Fipronil mixed with a second ingredient cyphenothrin. Fiproguard Max is the same product as Parastar Plus but by a different manufacturer. The two ingredients work together to provide dogs with protection to common topical parasites in dogs.
  • Parastar Plus® is for use in DOGS ONLY. Do not use in cats!
  • Fipronil is a phenylpyrazole antiparasitic agent primarily used to kill adult fleas and ticks. Fipronil works by interfering with the brain and spinal cord of insects, resulting in death. The efficacy and safety of Fipronil has been established since the mid 1990’s.
  • Cyphenothrin is a pyrethroid drug that works by interfering with nerve cells of susceptible insects resulting in paralysis and death of the parasite.
  • Parastar Plus and Fiproguard Max are both topical solutions that collect in the oils of the skin and in the hair follicles. It is not absorbed into the body and does not circulate through the blood stream. Through the process of translocation, it is spread over the body in about 24 hours.
    Parastar Plus and Fiproguard Max contain 9.8% Fipronil and 5.2% Cyphenothrin.
  • The effects of these products last about 30 days and remains effective after bathing or swimming though shampooing should be avoided within 48 hours of application. Parastar Plus and Fiproguard Max begins killing ticks in as little as 5 minutes.
  • Parastar Plus and Fiproguard Max are non-prescription flea and tick products and can be obtained without a veterinary prescription.

Brand Names and Other Names for Cyphenothrin

  • This drug is registered for use in animals only.
  • Human formulations: None
  • Veterinary formulations: Parastar Plus® (Novartis), Fiproguard Max® (Sentry)

Uses of Parastar Plus and Fiproguard Max®

  • Parastar Plus® and Fiproguard Max® are used for the control and treatment of adult flea and tick infestations in dogs… For more information on flea infestations, please see Flea Infestation in Dogs. Parastar Plus® and Fiproguard Max® kill Brown Dog ticks, Lone Star Ticks, American Dog Ticks, and Deer ticks.
  • Parastar Plus® and Fiproguard Max® are also used for treatment and control of chewing lice in dogs and puppies as well as aids in the control of sarcoptic mange infestations in dogs.

Precautions and Side Effects with Parastar Plus® and Fiproguard Max®

  • While generally safe and effective when prescribed by a veterinarian, fipronil can cause side effects in some animals.
  • Parastar Plus® and Fiproguard Max® should not be used in animals with known hypersensitivity or allergy to the drug.
  • Parastar Plus® is not recommended for use in puppies less than 12 weeks of age.
  • Parastar Plus® and Fiproguard Max® may interact with other medications. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with fipronil.
  • Parastar Plus® and Fiproguard Max® is a topical agent and temporary irritation at the site of application is possible.
  • Spotted areas may appear wet or oily for up to 24 hours over the area of application.
  • Overdose is is possible and can show signs of pyrethrin toxicity.

How Parastar Plus® and Fiproguard Max® is Supplied

  • Parastar Plus® is available in a topical solution available in the following sizes for dogs:

    • 4- 22 lbs (0.67ml tube)
    • 23 – 44 lbs (1.34 ml tube)
    • 45 – 88 lbs (2.68 ml tube)
    • 89 – 132 lbs (4.02 ml tube)
  • Fiproguard Max® is available in a topical solution available in the following sizes for dogs:

    • Dogs from 6.5 - 22 lbs.
    • Dogs from 23 - 44 lbs.
    • Dogs from 45 - 88 lbs.
    • Dogs from 89 - 132 lbs.

Dosing Information on Parastar Plus® and Fiproguard Max® for Dogs

  • Medication should never be administered without first consulting your veterinarian.
  • Parastar Plus® is labeled for dogs or puppies 12 weeks of age or older. Do not use for cats.
  • The dose of Parastar Plus® and Fiproguard Max® is based on the weight of the dog and pipettes are available in 0.67 mL (for dogs from 4 to 22 pounds), 1.34 mL (for dogs 23 to 44 pounds), 2.68 mL (for dogs 45 to 88 pounds) and 4.02 mL (for dogs 89 to 132 pounds). One pipette is applied topically every 30 days.
  • The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance.

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